Rational Fabrication of Folate-Conjugated Zein/Soy Lecithin/Carboxymethyl Chitosan Core–Shell Nanoparticles for Delivery of Docetaxel
Zhenyao Wu, Jie Li, Xin Zhang, Yangjia Li, Dongwei Wei, Lichang Tang, Shiming Deng, Guijin Liu
Abstract
= 1:15, DTX/FZLC NPs were obtained with high encapsulation efficiency (79.22 ± 0.37%), small particle size (206.9 ± 48.73 nm), and high zeta potential (-41.8 ± 3.97 mV). DTX was dispersed in the inner core of the FZLC matrix in an amorphous state. The results proved that DTX/FZLC NPs could increase the DTX dissolution, sustain the DTX release, and enhance the DTX cytotoxicity significantly. The present study provides insight into the formation of zein-based complex nanocarriers for the delivery of anticancer drugs.
Topics & Concepts
NanocarriersZeta potentialChitosanNanoparticleChemical engineeringSoy proteinChemistryNanocompositeNuclear chemistryDrug deliveryMaterials scienceNanotechnologyOrganic chemistryBiochemistryEngineeringNanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications