Regulation of kidney mitochondrial function by caloric restriction
Julian D. C. Serna, Andressa G. Amaral, Camille C. Caldeira da Silva, Ana Cláudia Munhoz, Eloisa Aparecida Vilas‐Boas, Sergio L. Menezes‐Filho, Alicia J. Kowaltowski
Abstract
Prevention of obesity through caloric restriction (CR) is well known to protect many tissues but has been poorly studied in kidneys. Here, we determined the effects of long-term CR in rat kidney mitochondria, which are central players in energy metabolism and aging. Surprisingly, we found that the diet increased mitochondrial reactive oxygen production and permeability transition. This suggests that the kidneys respond differently to restricted diets and may be more susceptible under CR.
Topics & Concepts
MitochondrionMitochondrial permeability transition poreBioenergeticsUniporterMitochondrial ROSBiologyReactive oxygen speciesOxidative phosphorylationHomeostasisMitochondrial apoptosis-induced channelInner mitochondrial membraneCell biologyBiochemistryChemistryCytosolProgrammed cell deathApoptosisEnzymeMitochondrial Function and PathologyBirth, Development, and HealthGenetics, Aging, and Longevity in Model Organisms