Wharton's jelly derived mesenchymal stem cells differentiate into oocyte like cells in vitro by follicular fluid and cumulus cells conditioned medium
Mona Zolfaghar, Leila Mirzaeian, Bahareh Beiki, Tahereh Naji, Ashraf Moini, Poopak Eftekhari‐Yazdi, Vahid Akbarinejad, Jennifer Vernengo, Rouhollah Fathi
Abstract
day onwards indicated that WJ-MSCs can differentiate into OLCs when exposed to FF and CCM. The size of produced OLCs and expression of oocyte specific genes and proteins were increased more positively in FF group rather than CCM group. Although, WJ-MSCs could differentiate into OLCs by FF and CCM, however, the induction potential of FF for producing OLCs was better than CCM.
Topics & Concepts
Wharton's jellyMesenchymal stem cellAndrologyOocyteFollicular fluidBiologyStem cellFollicular phaseCell biologyImmunologyEndocrinologyMedicineEmbryoReproductive Biology and FertilityMesenchymal stem cell researchTissue Engineering and Regenerative Medicine