Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, JI Jian-lin, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Topics & Concepts
CREBHippocampal formationNeurotrophic factorsHippocampusBehavioural despair testBrain-derived neurotrophic factorEndocrinologyInternal medicineNeuroscienceGene knockdownTail suspension testTropomyosin receptor kinase BCyclic adenosine monophosphateChronic stressPsychologyMedicineBiologyReceptorTranscription factorAntidepressantGeneticsApoptosisGeneNuclear Receptors and SignalingNerve injury and regenerationRNA Interference and Gene Delivery