TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease
Lina Herhaus
Abstract
TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and interferon (IFN) signaling, through selective autophagy, specifically mitophagy and xenophagy, to energy homeostasis. Thus, it is not surprising that TBK1 is involved in many cellular signaling pathways that contribute to diverse pathologies. In this review the role of TBK1 in autophagic signaling, especially mitophagy and xenophagy, and its contribution to oncogenesis or neurodegenerative diseases will be discussed.
Topics & Concepts
TANK-binding kinase 1MitophagyAutophagyCell biologyKinaseIκB kinaseULK1Signal transductionBiologyInnate immune systemPINK1Protein kinase AMAP kinase kinase kinaseImmunologyNF-κBImmune systemGeneticsAMPKApoptosisAutophagy in Disease and Therapyinterferon and immune responsesMosquito-borne diseases and control