Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites
Parbeen Singh, Brian Youden, Yikun Yang, Yongli Chen, Andrew Carrier, Shufen Cui, Ken D. Oakes, Mark R. Servos, Runqing Jiang, Xu Zhang
Abstract
Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.
Topics & Concepts
Photothermal therapyGlucose oxidaseMaterials scienceCancer therapyCancerCombinatorial chemistryNanotechnologyChemistryBiosensorMedicineInternal medicineNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniques