Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain
Lynn G. Schrag, Xiaorong Liu, Indhujah Thevarajan, Om Prakash, Michal Žółkiewski, Jianhan Chen
Topics & Concepts
Intrinsically disordered proteinsTransactivationBiologySuppressorMutationProtein–protein interactionCell biologyComputational biologyGeneticsBiophysicsCancerGeneTranscription factorCancer-related Molecular PathwaysProtein Structure and DynamicsRNA Research and Splicing