Palladium/NBE-Catalyzed Regioselective C–H Silylation: Access to Divergent Silicon-Containing Indoles
Wenguang Li, Wenguang Li, Man Cao, Chunyan Zhang, Shukui Shi, Juan Liu, Wentao Li, Wentao Li, Xu Zhang, Yongqi Yu, Ting Li
Abstract
A palladium/norbornene (NBE)-catalyzed regioselective C–H silylation of free NH-indoles is reported. This protocol uses Pd(OAc) 2 as the catalyst and Cu(OAc) 2 as the oxidant, and the reaction relies on the control of NBE as a switch. The reaction tolerates various functional groups, and a series of silicon-containing indoles were directly synthesized in 30%–94% yields.
Topics & Concepts
RegioselectivitySilylationChemistryPalladiumCatalysisNorborneneSiliconCombinatorial chemistryMedicinal chemistryOrganic chemistryPolymerizationPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques