Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
Emily M. Johansson, Delphine Bouchet, Ryad Tamouza, Pierre Ellul, AS. Morr, Elena Avignone, Raphaële Germi, Marion Leboyer, Hervé Perron, Laurent Groc
Abstract
-methyl-d-aspartate receptor (NMDAR)-mediated synaptic organization and plasticity through glia- and cytokine-dependent changes. Env expression in the developing hippocampus was sufficient to induce behavioral impairments at the adult stage that were prevented by Env neutralization or tuning of NMDAR trafficking. Thus, we show that a HERV gene product alters glutamate synapse maturation and generates behavioral deficits, further supporting the possible etiological interplay between genetic, immune, and synaptic factors in psychosis.
Topics & Concepts
Glutamate receptorSynapseEndogenyExcitatory synapseNeurosciencePsychosisExcitatory postsynaptic potentialBiologyExcitatory amino-acid transporterCell biologyMedicinePsychiatryGeneticsInhibitory postsynaptic potentialEndocrinologyReceptorGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchHIV Research and Treatment