Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis
Colleen M. Pike, John Tam, Roman A. Melnyk, Casey M. Theriot
Abstract
C. difficile infection (CDI) is a highly inflammatory disease mediated by the production of two large toxins that weaken the intestinal epithelium and cause extensive colonic tissue damage. Antibiotic alternative therapies for CDI are urgently needed as current antibiotic regimens prolong the perturbation of the microbiota and lead to high disease recurrence rates.
Topics & Concepts
Tauroursodeoxycholic acidUrsodeoxycholic acidBiologyDeoxycholic acidBile acidMicrobiologyApoptosisClostridium difficile toxin ATaurineToxinClostridium difficile toxin BAntibioticsClostridium difficilePharmacologyAmino acidBiochemistryUnfolded protein responseClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studies