Correlation between circulating innate lymphoid cell precursors and thymic function
Sandra Bajaña, Aneta Pankow, Kai‐Li Liu, Martyna Michniowska, Joseph F. Urban, Wei R. Chen, Xiao-Hong Sun
Abstract
cells differentiate into diverse ILC subsets in different tissue environments in steady state. Helminth infection promotes their differentiation toward functional ILC2s. Thus, the thymus appears to play a role in replenishing ILC pools in different peripheral tissues. Because thymic activity is age-dependent, this finding may help explain age-related differences in immune responses.
Topics & Concepts
Innate lymphoid cellBiologyInterleukin-7 receptorCell biologyImmune systemImmunologyCellular differentiationTranscription factorLymphatic systemLymphopoiesisImmunityHaematopoiesisT cellStem cellGeneGeneticsIL-2 receptorIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionEosinophilic Esophagitis