CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus
Vincent R. Graziano, Mia Madel Alfajaro, Cameron O. Schmitz, Renata B. Filler, Madison S. Strine, Jin Wei, Leon L. Hsieh, Megan T. Baldridge, Timothy J. Nice, Sanghyun Lee, Robert C. Orchard, Craig B. Wilen
Abstract
Human noroviruses (HuNoVs) are a leading cause of gastroenteritis resulting in up to 200,000 deaths each year. The receptor and cell tropism of HuNoV in immunocompetent humans are unclear.
Topics & Concepts
BiologyNorovirusConditional gene knockoutMurine norovirusStrain (injury)VirologyTropismKnockout mouseTissue tropismGeneticsPhenotypeVirusGeneAnatomyViral gastroenteritis research and epidemiologyAdvanced Thermodynamic Systems and EnginesViral Infections and Immunology Research