A novel family of small molecule HIF-1 alpha stabilizers for the treatment of diabetic wounds; an integrated<i>in silico</i>,<i>in vitro</i>, and<i>in vivo</i>strategy
M. Esakkimuthukumar, Akey Krishna Swaroop, Sunil Kumar Patnaik, Rajesh Raman, Praveen Thaggikuppe Krishnamurthy, Mudavath Ravi Naik, Jubie Selvaraj
Abstract
2,3,5-Tri substituted pyrazole analogues are identified as HIF-1α mimetics, which block the VHL interaction for diabetic wound healing therapy.
Topics & Concepts
In silicoIn vivoIn vitroAlpha (finance)ChemistryMoleculePharmacologyComputational biologyCombinatorial chemistryBiologyBiochemistryMedicineGeneticsSurgeryOrganic chemistryConstruct validityGenePatient satisfactionCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics