IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus
Jane Stremming, Sara Heard, Alicia White, Eileen I. Chang, Steven C. Shaw, Stephanie R. Wesolowski, Sonnet S. Jonker, Paul J. Rozance, Laura D. Brown
Abstract
After a 1-wk infusion of LR3 IGF-1, late gestation fetal sheep had lower umbilical uptake rates of amino acids, lower fetal arterial amino acid and insulin concentrations, and lower fetal oxygen content; however, LR-3 IGF-1-treated fetuses were still able to effectively utilize the available nutrients and oxygen to support organ growth and myoblast proliferation.
Topics & Concepts
FetusEndocrinologyInternal medicineInsulin-like growth factorFetal circulationGestationBiologyMedicinePlacentaPregnancyGrowth factorReceptorGeneticsGrowth Hormone and Insulin-like Growth FactorsBirth, Development, and HealthCancer Risks and Factors