Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Leila Abkhooie, Mostafa Moradi Sarabi, Houman Kahroba, Shirin Eyvazi, Soheila Montazersaheb, Vahideh Tarhriz, Mohammad Saeid Hejazi
Abstract
Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases.