ITLN1 exacerbates Crohn's colitis by driving ZBP1-dependent PANoptosis in intestinal epithelial cells through antagonizing TRIM8-mediated CAPN2 ubiquitination
Jie Zhao, Yujiang Li, Pu Ying, Yan Zhou, Ziwei Xu, Dongmei Wang, Honggang Wang, Liming Tang
Abstract
, establishing ITLN1-targeted therapies and PANoptosis modulation as viable clinical strategies for CD treatment.
Topics & Concepts
UbiquitinCrohn's diseaseColitisMedicineBiologyCancer researchInternal medicineBiochemistryDiseaseGeneinterferon and immune responsesInflammasome and immune disordersGalectins and Cancer Biology