Design, synthesis and biological evaluation of novel osimertinib derivatives as reversible EGFR kinase inhibitors
Shi Ding, Ziye Gao, Ziqiang Hu, Rui Qi, Xiangshan Zheng, Xiaoyong Dong, Mingjuan Zhang, Jiwei Shen, Tian Long, Yan Zhu, Lü Tian, Wenshan Song, Ruoqing Liu, Ying Li, Jiahuan Sun, Wenwen Duan, Ju Liu, Ye Chen
Topics & Concepts
T790MChemistryOsimertinibKinaseBiochemistryMolecular biologyPharmacologyEpidermal growth factor receptorGefitinibBiologyReceptorErlotinibLung Cancer Treatments and MutationsQuinazolinone synthesis and applicationsPI3K/AKT/mTOR signaling in cancer