Integrated separation and detection of exosomes <i>via</i> a label-free magnetic SERS platform
Lingfei Han, Chengcheng Zhu, Zheng Tan, Jin Wang, Xuewei Liao, Xing‐Hua Xia, Chen Wang
Abstract
nanoparticles as cores for separation and Au layers as shells for label-free SERS detection. Our method could effectively distinguish exosomes from different cell sources for cancer diagnosis and showed high sensitivity and specificity within a 95% confidence interval. As a low-cost and efficient exosome analysis method, the designed integrated platform for separation and detection has promising applicability in clinical diagnostics.
Topics & Concepts
Detection limitSuperparamagnetismRaman scatteringMagnetic separationNanotechnologyMaterials scienceMagnetic nanoparticlesNanoparticleChemistryRaman spectroscopyChromatographyMagnetizationOpticsMagnetic fieldPhysicsMetallurgyQuantum mechanicsExtracellular vesicles in diseaseGold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques