Identification of Actin Filament-Associated Proteins in Giardia lamblia
Melissa Steele-Ogus, Richard S. Johnson, Michael J. MacCoss, Alexander R. Paredez
Abstract
Giardia lamblia is an intestinal parasite that colonizes the small intestine and causes diarrhea, which can lead to dehydration and malnutrition. Giardia actin ( Gl Actin) has a conserved role in Giardia cells, despite being a highly divergent protein with none of the conserved regulators found in model organisms. Here, we identify and localize 46 interactors of polymerized actin.
Topics & Concepts
Giardia lambliaGiardiaActinBiologyParasite hostingIdentification (biology)MicrobiologyDiarrheaProtein filamentCell biologyBiochemistryEcologyMedicinePathologyComputer scienceWorld Wide WebParasitic Infections and DiagnosticsOrthopedic Infections and TreatmentsAmoebic Infections and Treatments