Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c
Matthew T. Remy, Adil Akkouch, He Li, Steven Eliason, Mason Sweat, Tadkamol Krongbaramee, Fan Fei, Fang Qian, Brad A. Amendt, Xuan Song, Liu Hong
Abstract
-incorporated scaffolds significantly enhanced bone regeneration in critical-sized rat calvarial defects. These results strongly indicate that bone grafts combining SEPS 3D-printed osteoconductive biomaterial-based scaffolds with osteoinductive miR-200c can be used as superior bone substitutes for the clinical treatment of large bone defects.
Topics & Concepts
Biomedical engineering3d printedMaterials scienceRegeneration (biology)BiomaterialMesenchymal stem cellNanotechnologyCell biologyBiologyMedicineBone Tissue Engineering MaterialsAdditive Manufacturing and 3D Printing Technologies3D Printing in Biomedical Research