Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions
Ketao Wang, Libo Jiang, Annan Hu, Chi Sun, Lei Zhou, Yiwei Huang, Qing Chen, Jian Dong, Xiaogang Zhou, Feng Zhang
Abstract
Our results indicated a unique feedback cycle between circulating NSCLC cells and VBMECs mediated by CX3CL1/ICAM-1 signaling, which is necessary for NSCLC spinal metastasis. This work provides a new perspective for underlying the mechanisms of NSCLC spinal metastasis and indicates potential novel targets for the prevention of NSCLC spinal metastasis.
Topics & Concepts
MedicineMetastasisCancer researchBone marrowPathologyLung cancerCellCancerBiologyInternal medicineGeneticsChemokine receptors and signalingCytokine Signaling Pathways and InteractionsCell Adhesion Molecules Research