Pannexin-1 channel opening is critical for COVID-19 pathogenesis
Ross H. Luu, Silvana Valdebenito, Eliana Scemes, Antonio Cibelli, David C. Spray, Maximiliano Rovegno, Juan E. Tichauer, Andréa Cottignies-Calamarte, Arielle R. Rosenberg, Calude Capron, Sandrine Belouzard, Jean Dubuisson, Djillali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth M. Cramer, Morgane Bomsel, Eliseo A. Eugenín
Abstract
, and IL-1β levels. Panx-1 channel opening induced by SARS-CoV-2 spike protein is angiotensin-converting enzyme 2 (ACE-2), endocytosis, and furin dependent. Overall, we demonstrated that Panx-1 channel is a critical contributor to SARS-CoV-2 infection and should be considered as an alternative therapy.
Topics & Concepts
PannexinFurinCoronavirusChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)EndocytosisCell biologyCoronaviridaeBiologyMedicineEnzymeReceptorConnexinBiochemistryDiseaseInternal medicineGap junctionIntracellularInfectious disease (medical specialty)Connexins and lens biologyHeme Oxygenase-1 and Carbon MonoxideThermal Regulation in Medicine