Fetal Growth Restriction and Asthma: Is the Damage Done?
Kimberley C. W. Wang, Alan James, Peter B. Noble
Abstract
Trajectories of airway remodeling and functional impairment in asthma are consistent with the notion that airway pathology precedes or coincides with the onset of asthma symptoms and may be present at birth. An association between intrauterine growth restriction (IUGR) and asthma development has also been established, and there is value in understanding the underlying mechanism. This review considers airway pathophysiology as a consequence of IUGR that increases susceptibility to asthma.
Topics & Concepts
AsthmaIntrauterine growth restrictionAirwayMedicinePathophysiologyFetusMechanism (biology)Fetal growthImmunologyPregnancyInternal medicineBiologyGeneticsAnesthesiaEpistemologyPhilosophyNeonatal Respiratory Health ResearchBirth, Development, and HealthInfant Nutrition and Health