Clinical Relevance of Myopenia and Myosteatosis in Colorectal Cancer
Yoshinaga Okugawa, Takahito Kitajima, Akira Yamamoto, Tadanobu Shimura, Mikio Kawamura, Takumi Fujiwara, Ikuyo Mochiki, Yoshiki Okita, Masahiro Tsujiura, Takeshi Yokoe, Masaki Ohi, Yuji Toiyama
Abstract
Sarcopenia was initially described as a decrease in muscle mass associated with aging and subsequently also as a consequence of underlying disease, including advanced malignancy. Accumulating evidence shows that sarcopenia has clinically significant effects in patients with malignancy, including an increased risk of adverse events associated with medical treatment, postoperative complications, and a poor survival outcome. Colorectal cancer (CRC) is one of the most common cancers worldwide, and several lines of evidence suggest that preoperative sarcopenia negatively impacts various outcomes in patients with CRC. In this review, we summarize the current evidence in this field and the clinical relevance of sarcopenia in patients with CRC from three standpoints, namely, the adverse effects of medical treatment, postoperative infectious complications, and oncological outcomes.