Highly diastereo- and enantioselective synthesis of spiro β-lactams <i>via</i> copper-catalyzed Kinugasa/aldol cascade reaction
Jie Li, Haowen Ma, Xianqiang Zhong, Shanyue Li, Jiehao Zhang, Yun‐Lin Ao, Wei Zhou, Qian Cai
Abstract
A copper( i )-catalyzed highly diastereo- and enantioselective Kinugasa/aldol cascade reaction of N -(2-acylaryl) propiolamides with nitrones has been demonstrated for efficient synthesis of structurally novel chiral spiro β-lactams.
Topics & Concepts
Enantioselective synthesisAldol reactionChemistryCascadeCatalysisCopperCascade reactionCombinatorial chemistryStereochemistryOrganic chemistryChromatographySynthesis of β-Lactam CompoundsSynthesis and Biological EvaluationSynthesis and Catalytic Reactions