Boromycin Has Potent Anti-<i>Toxoplasma</i>and Anti-<i>Cryptosporidium</i>Activity
Jaypee Abenoja, Alexis Cotto-Rosario, Roberta M. O’Connor
Abstract
Toxoplasma gondii and Cryptosporidium parvum , members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here, we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium . Boromycin potently inhibited intracellular proliferation of both T. gondii and C. parvum at half-maximal effective concentrations (EC 50 ) of 2.27 nM and 4.99 nM, respectively.
Topics & Concepts
Cryptosporidium parvumApicomplexaToxoplasma gondiiCryptosporidiumMicrobiologyProtozoaBiologyIntracellularAntibioticsVirologyIntracellular parasiteProtozoal diseaseAntibodyImmunologyBiochemistryFecesMalariaToxoplasma gondii Research StudiesParasitic Infections and DiagnosticsCoccidia and coccidiosis research