Synthesis and <i>in vitro</i> preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer
Axel Cordonnier, Damien Boyer, Sophie Besse, Rodolphe Valleix, Rachid Mahiou, Mercédès Quintana, Arnaud Briat, Mhammed Benbakkar, Frédérique Penault‐Llorca, Aurélie Maisonial‐Besset, Benoı̂t Maunit, Sébastien Tarrit, Magali Vivier, Tiffany Witkowski, Leslie Mazuel, Françoise Degoul, Elisabeth Miot-Noirault, Jean‐Michel Chezal
Abstract
Upconverting nanoparticles were synthesized, hydrophilized and functionalized to efficiently target PSMA positive prostate cancer cells.
Topics & Concepts
LNCaPBiophysicsChemistryNanoparticleNanomedicineMaterials scienceCombinatorial chemistryNanotechnologyProstate cancerMedicineBiologyCancerInternal medicineLuminescence Properties of Advanced MaterialsNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials