Halocyclization of Olefinic 1,3-Dicarbonyls and Olefinic Amides in Aqueous Media Open in Air at Room Temperature
Tingting Cao, Weikang Zhang, Fu‐Hua Qin, Qing‐Qing Kang, Youren Dong, Qiang Li, Chao Kang, Wen‐Ting Wei
Abstract
A green and efficient procedure for the preparation of valuable 2,3-dihydrofurans and benzoxazines has been achieved through halocyclization of olefinic 1,3-dicarbonyls or olefinic amides. This protocol could be conducted under catalyst-, base-, and oxidant-free conditions in aqueous media open to the air at room temperature with good to excellent yields. Notably, the practicality of this method is further highlighted by gram-scale reactions in good yields.
Topics & Concepts
Aqueous mediumChemistryCatalysisOpen airAqueous solutionOrganic chemistryGreen chemistryBase (topology)Reaction mechanismEngineeringMathematicsMathematical analysisArchitectural engineeringSynthesis and Biological EvaluationMulticomponent Synthesis of HeterocyclesChemical Synthesis and Reactions