Cellular reprogramming as a tool to model human aging in a dish
Patrícia R. Pitrez, Luís Miguel Monteiro, Oliver Borgogno, Xavier Nissan, Jérôme Mertens, Lino Ferreira
Abstract
The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
Topics & Concepts
ReprogrammingInduced pluripotent stem cellHuman Induced Pluripotent Stem CellsCellular AgingLife spanPsychological interventionHuman healthCellular modelPerspective (graphical)Computational biologyBiologyNeuroscienceComputer scienceMedicineEvolutionary biologyCell cultureEmbryonic stem cellCellGeneticsArtificial intelligencePsychiatryGeneEnvironmental healthTelomerePluripotent Stem Cells ResearchGenetics, Aging, and Longevity in Model Organisms3D Printing in Biomedical Research