HLA-E–restricted, Gag-specific CD8 <sup>+</sup> T cells can suppress HIV-1 infection, offering vaccine opportunities
Hongbing Yang, Margarida Rei, Simon Brackenridge, Elena Brenna, Hong Sun, Shaheed Abdulhaqq, Michael K. P. Liu, Weiwei Ma, Prathiba Kurupati, Xiao‐Ning Xu, Vincenzo Cerundolo, Edward Jenkins, Simon J. Davis, Jonah B. Sacha, Klaus Früh, Louis J. Picker, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael
Abstract
T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible.
Topics & Concepts
VirologyHuman immunodeficiency virus (HIV)CD8ImmunologyBiologyHuman leukocyte antigenCytotoxic T cellAntigenGeneticsIn vitroImmune Cell Function and InteractionHIV Research and TreatmentT-cell and B-cell Immunology