Overview of the regulation of the class IA PI3K/AKT pathway by SUMO
Santiago Vidal, Yanis Hichem Bouzaher, Ahmed El Motiam, Rocío Seoane, Carmen Rivas
Abstract
The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is a major regulator of metabolism, migration, survival, proliferation, and antiviral immunity. Both an overactivation and an inhibition of the PI3K/AKT pathway are related to different pathologies. Activation of this signaling pathway is tightly controlled through a multistep process and its deregulation can be associated with aberrant post-translational modifications including SUMOylation. Here, we review the complex modulation of the PI3K/AKT pathway by SUMOylation and we discuss its putative incvolvement in human disease.
Topics & Concepts
PI3K/AKT/mTOR pathwaySUMO proteinProtein kinase BRegulatorCell biologyPhosphatidylinositolSignal transductionBiologyGeneticsGeneUbiquitinPI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathwaysBiochemical and Molecular Research