IL-8 secreted by tumor associated macrophages contribute to lapatinib resistance in HER2-positive locally advanced breast cancer via activation of Src/STAT3/ERK1/2-mediated EGFR signaling
Shaza Ahmed, Hossam Taha Mohamed, Noura El-Husseiny, Manal M. El Mahdy, Gehan Safwat, Ayman A. Diab, Ahmed A. El‐Sherif, Mohamed El‐Shinawi, Mona Mostafa Mohamed
Topics & Concepts
LapatinibCancer researchCytokineMedicineTyrosine-kinase inhibitorTumor microenvironmentBreast cancerReceptor tyrosine kinaseTyrosine kinaseSignal transductionEpidermal growth factor receptorTrastuzumabCancerReceptorImmunologyBiologyInternal medicineCell biologyHER2/EGFR in Cancer ResearchHistone Deacetylase Inhibitors ResearchImmune cells in cancer