Pd(II)-Catalyzed Enantioselective C(sp <sup>3</sup> )–H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
Jesus Rodrigalvarez, Luke A. Reeve, Javier Miró, Matthew J. Gaunt
Abstract
-isobutyl tertiary alkylamines. This straightforward and operationally simple method simplifies the construction of functionalized aminomethyl-strained cycloalkanes, which we believe will find widespread use in academic and industrial settings relating to the synthesis of biologically active small molecules.
Topics & Concepts
ChemistryEnantioselective synthesisCyclobutanesArylDesymmetrizationStereochemistryCatalysisDiastereomerCombinatorial chemistryMedicinal chemistryOrganic chemistryCycloadditionAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis