<p>Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?</p>
Heng Cai, Wenjing Liu, Xiaobai Liu, Zhiqing Li, Tianda Feng, Yixue Xue, Yunhui Liu
Abstract
Vasculogenic mimicry (VM) is the formation of a "vessel-like" structure without endothelial cells. VM exists in vascular-dependent solid tumors and is a special blood supply source involved in the highly invasive tumor progression. VM is observed in a variety of human malignant tumors and is closely related to tumor proliferation, invasion, and recurrence. Here, we review the mechanism, related signaling pathways, and molecular regulation of VM in glioma and discuss current research problems and the potential future applications of VM in glioma treatment. This review may provide a new viewpoint for glioma therapy.
Topics & Concepts
Vasculogenic mimicryGliomaMedicineCancer researchMimicryNeuroscienceInternal medicineBiologyCancerZoologyMetastasisGlioma Diagnosis and TreatmentAngiogenesis and VEGF in CancerCircular RNAs in diseases