An efficient and straightforward approach for accessing thionoesters <i>via</i> palladium-catalyzed C–N cleavage of thioamides
Yinbo Liu, Xiaofeng Mo, Majeed Irfan, Mei Zhang, Hui Wang, Zhuo Zeng
Abstract
a palladium-catalyzed C-N cleavage strategy. The new approach employs thioamides as a thioacylating reagent to give thionoesters in moderate to good yields. Notably, this methodology demonstrates a broad substrate scope, as alkyl/aryl alcohols are well tolerated, and this process might facilitate the synthesis of sulfur-containing compounds under simple and mild conditions.
Topics & Concepts
ChemistryPalladiumArylReagentCleavage (geology)CatalysisCombinatorial chemistryAlkylSulfurSubstrate (aquarium)Organic chemistryGeotechnical engineeringGeologyOceanographyFracture (geology)EngineeringSynthesis and Reactivity of Sulfur-Containing CompoundsSynthesis of heterocyclic compoundsSulfur-Based Synthesis Techniques