Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem
Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Abstract
were found to lower the minimum inhibitory concentration (MIC) of Meropenem up to 128-fold against strains producing NDM- and VIM-type enzymes.
Topics & Concepts
MeropenemIsothermal titration calorimetryAcinetobacter calcoaceticusCarbapenemChemistryEnzymeDissociation constantMicrobiologyAcinetobacter baumanniiBiochemistryStereochemistryMinimum inhibitory concentrationErtapenemEnzyme kineticsBacteriaAcinetobacterBiologyIn vitroActive siteAntibioticsAntibiotic resistancePseudomonas aeruginosaGeneticsReceptorAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyTuberculosis Research and Epidemiology