The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
David R. Goldsmith, Nicholas Massa, Brian J. Miller, Andrew H. Miller, Erica Duncan
Abstract
Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.
Topics & Concepts
Schizophrenia (object-oriented programming)Negative symptomInflammationIllness severityClinical psychologyMedicinePsychosisPsychiatryPsychologyInternal medicineSeverity of illnessTryptophan and brain disordersSchizophrenia research and treatmentStress Responses and Cortisol