Enhanced synthesis of chloramphenicol intermediate L-threo-p-nitrophenylserine using engineered L-threonine transaldolase and by-product elimination
Zhiwen Xi, Yan Xu, Zhiyong Liu, Xinyi Zhang, Qiang Zhu, Lihong Li, Rongzhen Zhang
Topics & Concepts
TransaldolaseChemistryDirected evolutionEnantiomeric excessAlcohol dehydrogenaseFormate dehydrogenaseCombinatorial chemistryBiocatalysisStereochemistrySaturated mutagenesisBiochemistryMutantCatalysisEnzymeEnantioselective synthesisFormateReaction mechanismPentose phosphate pathwayGeneGlycolysisEnzyme Catalysis and ImmobilizationAmino Acid Enzymes and MetabolismCarbohydrate Chemistry and Synthesis