Foxo3 Promotes the Differentiation and Function of Follicular Helper T Cells
Haiyu Qi, Dan Tian, Mingyang Li, Chunpan Zhang, Hua Jin, Liwei Liu, Xinyan Zhao, Linlin Ma, Weijia Zhao, Qing Ge, Ting Duan, Dong Zhang
Abstract
mice proves that wild-type (WT), but not Foxo3-deficient T cells provoke GC B cell maturation and antibody production. Deficiency of Foxo3 inhibits inducible T cell co-stimulator (ICOS)-induced Tfh differentiation. Chromatin immunoprecipitation assay results suggest that Foxo3 is able to bind to the IL-21 promoter and regulate IL-21 secretion. In conclusion, our study unveils a critical role of Foxo3 in the regulation of Tfh differentiation and IL-21 production. Modulating Foxo3 activity may be beneficial for enhancing or preventing antibody-mediated immune responses.
Topics & Concepts
FOXO3Follicular phaseFunction (biology)Cell biologyBiologyGeneticsSignal transductionProtein kinase BFOXO transcription factor regulationT-cell and B-cell ImmunologyCancer-related molecular mechanisms research