CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
Vı́ctor Agmo Hernández, Jessika Carvajal‐Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gülçin Özer, Jack C. Yalowich, Terry S. Elton
Topics & Concepts
BiologyTopoisomeraseMolecular biologyGeneIntronDNAExonCas9DNA damageCRISPREtoposideK562 cellsGeneticsChemotherapyCancer therapeutics and mechanismsAdvanced biosensing and bioanalysis techniquesRenal Transplantation Outcomes and Treatments