Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Abstract
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.
Topics & Concepts
Photodynamic therapyCytotoxicityMelanomaRutheniumImmunogenic cell deathCancer researchCytotoxic T cellProgrammed cell deathImmunotherapyPhotosensitizerMedicineChemistryApoptosisImmunologyImmune systemIn vitroBiochemistryPhotochemistryCatalysisOrganic chemistryNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery