Conversion of amino-terephthalonitriles to multi-substituted single benzene fluorophores with utility in bioimaging
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Abstract
Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through S N Ar chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
Topics & Concepts
FluorineSubstitution (logic)BenzeneAmine gas treatingChemistryCombinatorial chemistryPhotochemistryNanotechnologyOrganic chemistryMaterials scienceComputer scienceProgramming languageFluorine in Organic ChemistryClick Chemistry and ApplicationsOrganic Chemistry Cycloaddition Reactions