Intramolecular Ni-catalyzed reductive coupling enables enantiodivergent synthesis of linoxepin
Zi-Hao Liu, Jian Xiao, Qianqian Zhai, Xi Tang, Li-Jun Xu, Zhiyuan Zhuang, Ya‐Wen Wang, Yu Peng
Abstract
The first enantiodivergent synthesis of pentacyclic natural product linoxepin was achieved by late-stage oxidation of a diastereodivergent core, which could be synthesized by a unique nickel-catalyzed intramolecular reductive coupling.
Topics & Concepts
Intramolecular forceCatalysisCoupling (piping)ChemistryCombinatorial chemistryStereochemistryMaterials scienceOrganic chemistryMetallurgyCatalytic C–H Functionalization MethodsAlkaloids: synthesis and pharmacologyChemical synthesis and alkaloids