Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates
Musa A. Said, Sayed M. Riyadh, Nadia S. Al‐Kaff, AbdElAziz A. Nayl, Khaled D. Khalil, Stefan Bräse, Sobhi M. Gomha
Abstract
were inactive in all five similar to that found with Remdesivir and Ivermectin. The drug-likeness prediction was carried out by studying physicochemical properties, lipophilicity, size, polarity, insolubility, unsaturation, and flexibility. Generally, some properties of the ligands were comparable to that of the standards used in this study, Remdesivir and Ivermectin.
Topics & Concepts
ChemistryLigand (biochemistry)ThiadiazolesStereochemistryHOMO/LUMODocking (animal)Medicinal chemistryNuclear chemistryOrganic chemistryMoleculeReceptorBiochemistryMedicineNursingSynthesis and biological activityComputational Drug Discovery MethodsResearch on Leishmaniasis Studies