Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers
Rachel Joyce, Rosa Pascual, Luuk Heitink, Bianca D. Capaldo, François Vaillant, Michael Christie, Minhsuang Tsai, Elliot Surgenor, Casey J. A. Anttila, Pradeep Rajasekhar, Felicity C. Jackling, Marie Trussart, Michael J. G. Milevskiy, Xiaoyu Song, Mengbo Li, Charis E. Teh, Daniel H.D. Gray, Gordon K. Smyth, Yunshun Chen, Geoffrey J. Lindeman, Jane E. Visvader
Topics & Concepts
Breast cancerCancer researchProgenitor cellBiologyBRCA2 ProteinCarcinogenesismTORC1CancerProteostasisMutationStem cellCell biologyGeneticsGermline mutationSignal transductionGenePI3K/AKT/mTOR pathwayBRCA gene mutations in cancerCRISPR and Genetic EngineeringCancer Genomics and Diagnostics