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Validation of a novel UPLC-MS/MS method for estimation of metformin and empagliflozin simultaneously in human plasma using freezing lipid precipitation approach and its application to pharmacokinetic study

Mona N. Abou-Omar, Mohamed Kenawy, Ahmed O. Youssef, Sarah Alharthi, Mohamed S. Attia, Ekram H. Mohamed

2021Journal of Pharmaceutical and Biomedical Analysis24 citationsDOI

Topics & Concepts

ChemistryEmpagliflozinChromatographyProtein precipitationEMPAPharmacokineticsAnalyteFormic acidSelected reaction monitoringHigh-performance liquid chromatographyMass spectrometryTandem mass spectrometryPharmacologyType 2 diabetesDiabetes mellitusMedicineEndocrinologyElectron microprobeMineralogyDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerDiabetes Management and Research
Validation of a novel UPLC-MS/MS method for estimation of metformin and empagliflozin simultaneously in human plasma using freezing lipid precipitation approach and its application to pharmacokinetic study | Litcius