Unacylated ghrelin, leptin, and appetite display diurnal rhythmicity in lean adults
Iain Templeman, Harry Smith, Jean‐Philippe Walhin, Benita Middleton, Javier T. Gonzalez, Leonidas G. Karagounis, Jonathan D. Johnston, James A. Betts
Abstract
Simultaneous assessment of subjective appetite, unacylated ghrelin, and leptin was carried out over a continuous 37-h protocol for the first time under conditions of controlled light, sleep, and feeding in healthy, lean adults. Rhythms were observed in unacylated ghrelin, leptin, and components of subjective appetite, such as hunger, prospective consumption, and fullness. Concurrent measurement of rhythms in these variables is important to fully understand the temporal relationships between components of appetite as well as the influence of diurnal factors such as sleep, light, and feeding.
Topics & Concepts
GhrelinAppetiteLeptinCircadian rhythmEndocrinologyInternal medicineAnorexiaSleep (system call)Energy expenditureObesityMedicinePsychologyHormoneComputer scienceOperating systemRegulation of Appetite and ObesityBiochemical Analysis and Sensing TechniquesDietary Effects on Health