Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation
Rizky I. Sugianto, Nima Memaran, Bernhard M. W. Schmidt, Anke Doyon, Daniela Thurn‐Valsassina, Harika Alpay, Ali Anarat, Klaus Arbeiter, Karolis Ažukaitis, Aysun Karabay Bayazıt, İpek Kaplan Bulut, Salim Çalışkan, Nur Canpolat, Ali Düzova, Jutta Gellerman, Jérôme Harambat, Denise Homeyer, Mieczysław Litwin, Francesca Mencarelli, Łukasz Obrycki, Dušan Paripović, Bruno Ranchin, Rukshana Shroff, Uwe Tegtbur, Jeannine von der Born, Ebru Yılmaz, Uwe Querfeld, Elke Wühl, Franz Schaefer, Anette Melk
Abstract
per year pre-kidney replacement therapy and a longer time (over 12 months) to transplantation were significantly associated with higher PWVz of 0.22 and of 0.57, respectively. PWVz increased further after transplantation and was positively associated with time on dialysis and diastolic blood pressure in both sexes. Thus, our findings demonstrate that girls with advanced chronic kidney disease are more susceptible to develop vascular stiffening compared to boys, this difference persist after transplantation and might contribute to higher mortality rates seen in girls with kidney failure.