Bioinformatics-guided discovery of biaryl-linked lasso peptides
Hamada Saad, Thomas Majer, Keshab Bhattarai, Sarah Lampe, Dinh Thanh Nguyen, Markus Krämer, Jan Straetener, Heike Brötz‐Oesterhelt, Douglas A. Mitchell, Harald Gross
Abstract
Genome mining enabled the discovery of a series of unique lasso peptides. They contain a P450-mediated C–N-based biarylic crosslink at the lasso ring and can in addition bear a unique sulfonium residue.
Topics & Concepts
Computational biologyLasso (programming language)Drug discoveryBioinformaticsComputer scienceBiologyWorld Wide WebChemical Synthesis and AnalysisMicrobial Natural Products and BiosynthesisMonoclonal and Polyclonal Antibodies Research