Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer
Dimitrios Stefanoudakis, Maximos Frountzas, Dimitriοs Schizas, Nikolaos V. Michalopoulos, Alexandra Drakaki, Konstantinos G. Toutouzas
Abstract
The present review demonstrates the major tumor suppressor genes, including TP53, CDKN2A and SMAD4, associated with pancreatic cancer. Each gene's role, prevalence and impact on tumor development and progression are analyzed, focusing on the intricate molecular landscape of pancreatic cancer. In addition, this review underscores the prognostic significance of specific mutations, such as loss of TP53, and explores some potential targeted therapies tailored to these molecular signatures. The findings highlight the importance of genomic analyses for risk assessment, early detection and the design of personalized treatment approaches in pancreatic cancer. Overall, this review provides a comprehensive analysis of the molecular intricacies of pancreatic tumors, paving the way for more effective and tailored therapeutic interventions.